SLC11A1 solute carrier family 11 member 1 [Homo sapiens (human)]
Posted on: Wednesday, April 13th, 2022 | ID: #831

Official Symbol SLC11A1provided by HGNC Official Full Name solute carrier family 11 member 1provided by HGNC Primary source HGNC:HGNC:10907 See related Ensembl:ENSG00000018280 MIM:600266; AllianceGenome:HGNC:10907 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSH; NRAMP; NRAMP1 Summary This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 10.4), appendix (RPKM 8.8) and 7 other tissues See more Orthologs mouse all NEW Try the new Gene table
Try the new Transcript table Exon count: 18

Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218382273..218396894)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218868403..218883023)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219246996..219261617)

Chromosome 2 – NC_000002.12Genomic Context describing neighboring genes

HPA RNA-seq normal tissues RNA sequencing of total RNA from 20 human tissues Illumina bodyMap2 transcriptome Tissue-specific circular RNA induction during human fetal development

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Related articles in PubMed

  1. Association of genetic variants in autophagy-lysosome pathway genes with susceptibility and survival to prostate cancer. Zhu Q, et al. Gene, 2022 Jan 15. PMID 34500048
  2. SLC11A1 (rs3731865) polymorphism and susceptibility to visceral leishmaniasis in HIV-coinfected patients from Northeastern Brazil. Barbosa Júnior WL, et al. Parasitol Res, 2020 Feb. PMID 31907667
  3. Correlation of Polymorphisms of Natural Resistance-Associated Macrophage Protein 1 (NRAMP1) Gene and Smoking with the Risk of Rheumatoid Arthritis in Chinese Han People. Zou Q, et al. Med Sci Monit, 2019 Jul 18. PMID 31316048, Free PMC Article
  4. Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas. Ouyang C, et al. J Cancer Res Ther, 2019. PMID 30964110
  5. SLC11A1 is expressed in the human placenta across multiple gestational ages. Perry ID, et al. Placenta, 2019 Jan. PMID 30712662

See all (191) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

Preferred Names natural resistance-associated macrophage protein 1 Names NRAMP 1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 solute carrier family 11 (sodium/phosphate symporters), member 1

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